Not ignoring you; just haven't seen this particular problem before, and I don't know that either point below will explain the problem.
I have seen the Tiptronic become stuck in a gear - it happened to me once when I shut down without returning the lever to the normal automatic shift slot. Re-starting, shutting down, then moving the lever out of Tiptronic cured the problem (as I recall; it was 7 years ago).
Also, unusual electronic "glitches" that go away after restart are sometimes caused by a failing battery. You might want to check yours. There are some battery troubleshooting links in the W220 S-Class Owners Start Here sticky at the top of the W220 forum.
We'll be interested in what you find.
2010 S550 w/AMG
Sport appearance package
2005 S500 4-Matic
1978 450SL restoration project
Last edited by Skylaw; 05-13-2010 at 09:33 AM.