S-Class (W220) 1999-2006: S 320 CDI, S 320, S430, S 500, S 600

2004 S600: Cyl 1-6 Misfire after 3 seconds of Starting Engine

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Old Nov 1, 2021 | 06:53 PM
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2004 S600: Cyl 1-6 Misfire after 3 seconds of Starting Engine

Hey guys. I'm facing an unusual problem. I bought a 2004 S600 with a misfire on 1-6. I figure coil pack, vt, etc. The regular, why walk away from it. It's a fun project.

Ordered my CP (from Clark) and bought a new VT (reman) from MB.

Installed all today and still the same miss. Cleared the codes, still the same thing. Starts up fine, after 3-4 seconds; CEL & misfire 1-6.

I did notice a tube with a vacuum hose coming off the right IC that isn't attached to anything. Could this be the cause, or am I chasing the wrong thread?

I haven't looked, but does SDS have an area to testO2 sensors & MAP sensors?

All help is truly appreciated!
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Old Nov 1, 2021 | 08:12 PM
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Anything unplugged could be a problem

check spark plugs and O2 sensors are both known for. Misfire on the v12 , it’s not always coil pack or vt
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Old Nov 1, 2021 | 09:05 PM
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Originally Posted by tusabes
Anything unplugged could be a problem

check spark plugs and O2 sensors are both known for. Misfire on the v12 , it’s not always coil pack or vt
Im planning on going thriugh it again tomorrow.

I also plan to change plugs at the same time.

How can I tell if O2 sensors are bad?
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Old Nov 1, 2021 | 10:56 PM
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At this age they are all worn and needing replacement
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Old Nov 2, 2021 | 11:53 AM
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2009 E350 4M Avantgarde;mistress 2002 S600; wife 2014 C300 4M
You need to approach this systematically:
1) You need to read the misfire code with SDS (nothing else will do it). If it shows Misfire 1 - 6 TWC DAMAGE, it means the ECU shuts that bank down to protect the cats.
2) You need somebody with the necessary skill to read the O2 sensors on that side "live" with SDS
3) if the O2 sensors are "off", you can change them, but sometimes you can you need to check the cats, and then you can shim the sensors "out" the improve the reading. (there are also shims available with their own catalyst values.) NOT from MB!
4) The transformer you installed MUST match the part number for your engine model; if not will not work right.
Good luck!
BTW: The above codes always clear on next start, and then reappear.
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Old Nov 2, 2021 | 08:11 PM
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Misfire Listing

The red line is right O2 sensor

Upstream Engine On

Upstream Engine Off

Downstream Engine On

Downstream Engine Off



These O2 numbers look normal?

Car starts up fine, but then gets CEL and shuts off right bank after 3-4 seconds.

Fixed the vacuum leaks and got new spark plugs this morning before these pictures. So its safe to say those two items can be ruled out, on top of the new coilpack and VT.
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Old Nov 3, 2021 | 08:28 AM
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2009 E350 4M Avantgarde;mistress 2002 S600; wife 2014 C300 4M
The answer is in your first image: The ECU is shutting down that bank to protect the cats due to O2 values.
Get some good Indie help; don't throw parts at it.
Good luck!
BTW: 2.7.1 is for M137; you should be 2.8.1 for your engine model M275 (I believe)

Last edited by kraut56; Nov 3, 2021 at 08:32 AM.
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Old Nov 3, 2021 | 08:57 AM
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Originally Posted by kraut56
The answer is in your first image: The ECU is shutting down that bank to protect the cats due to O2 values.
Get some good Indie help; don't throw parts at it.
Good luck!
BTW: 2.7.1 is for M137; you should be 2.8.1 for your engine model M275 (I believe)
SDS auto selected the ME.

I was thinking of replacing O2 and then looking at the CATS for possibly being damaged or plugged.

I want to do as much as I can before sending it to the Independent.

Based on the pictures, do you think its upstream or downstream O2 causing issues; or both?

Thanks in advance!
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Old Nov 6, 2021 | 03:30 PM
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BTT
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Old Dec 18, 2021 | 06:11 PM
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Still looking for a solution to this problem. Any other ideas out there?
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Old Jan 31, 2022 | 01:14 PM
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CL 600 '00 5.8L V12
Did you end up solving this issue?
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Old Jan 31, 2022 | 06:39 PM
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Originally Posted by tim687
Did you end up solving this issue?
Nope. Any ideas?
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Old May 11, 2022 | 05:53 AM
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CL 600 '00 5.8L V12
Did you inspect the cats?
Also these cars are very sensitive to proper fuel, so make sure that you use the correct fuel.
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Old May 11, 2022 | 06:06 PM
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Originally Posted by tim687
Did you inspect the cats?
Also these cars are very sensitive to proper fuel, so make sure that you use the correct fuel.
I just put a full tank of fresh premium grade. I have not inspected the cats.

I was told that it could be a bad ECU. I am trying to figure out how to check an ECU.
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Old May 12, 2022 | 12:37 AM
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CL 600 '00 5.8L V12
Unscrew the downstream O2 sensor an try again. If the car starts to run fine, welcome to the clogged cat club (CCC)
😜
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Old May 12, 2022 | 07:14 AM
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Originally Posted by tim687
Unscrew the downstream O2 sensor an try again. If the car starts to run fine, welcome to the clogged cat club (CCC)
😜
I did try that and it still misses
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Old May 12, 2022 | 11:55 AM
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CL 600 '00 5.8L V12
Why did they think it was a bad ECU? You could try to reset the ECU through DAS/Xentry

Also, https://mbworld.org/forums/w211-amg/...ispreloading=1

This sometimes seems to help
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Old Dec 21, 2025 | 04:49 AM
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Issue Solved?

Reviving this thread because I am coming across the exact same issue with my CL65. Did it end up being the ECU? I've replaced O2 sensors and other bank specific sensors, ignition is all in good order, so I am stumped! What ended up being the problem?

Thanks!
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Old Jun 8, 2026 | 01:16 PM
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Anyone checking vacuum lines in the m275 should remove the intake manifold and check the lines under the intake manifold because that is where mines were snapped. No idea why mercedes put the vacuum box underneath the intake manifold. Change out the intake manifold gasket while you have the manifold off and change the vacuum lines with some high quality silicone vacuum lines and never have to deal with the vacuum lines again. I am still looking into my missfires
as well. Ai seems to think it could be a weak grond ? I will be adding more ground wires to see if that helps. Here is a picture of the vacuum box that sits under the intake manifold. Since I had them out already I took my injectors to get flow matched and found out that 2 of them needed replacing
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Old Jun 8, 2026 | 01:31 PM
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Hank many moons ago I had heard that replacement of that vacuum reservoir requires pulling heads. Something about not being able to access fasteners. Is that accurate?
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Old Jun 15, 2026 | 03:25 AM
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You have to remove the intake manifold and the vacuum box is directly underneath it. Ill give you a quick break down. You'll need the intake manifold gasket and throttle body gasket. It's pretty straight forward . removeing the intake manifold does take some work. The air box and Intercooler need to be removed, then the voltage transformer, the fuel rail is the tricky part, there's these brackets towards the firewall with 4 t30 or t40 bolts I forget but the only way I found to remove them was to use a long 6 inch torx bit. Once you get this bracket out everything else is easy. You might want to get your injectors serviced and flow matched. Two of mine were no good. One sprayed too much and the other too little. Your vacuum box is probably fine but the hose will either have snapped or is about to. The hard line has become extremely brittle with age. Change it all out with high quality vacuum hose and hose clamps so they don't leak. Make sure to take photos of your vacuum line lay out. There is a vacuum diagram in top of the radiator support but i find photos easier to follow. The hose is pretty deep i found a pic from alibaba to show you just how deep it is.



Here is a picture of the two brackets that are a bit difficult to remove.


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Old Jun 15, 2026 | 03:28 AM
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Yes you are correct about pulling heads if you want to replace the vacuum box but your box should be fine, it's the hoses that are an issue.
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Old Jun 16, 2026 | 11:55 AM
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Of course one has to wonder exactly which problem Mercedes solved burying a plastic vacuum reservoir under the intake manifold because obviously that thing and hoses to it wouldn't be guaranteed to fail.... (years our of warranty)

I recall that bracket which charge coolers mount to ect when replacing the 275 in my 221 car.

The intake manifold that feeds a pair of intake valves per hole is a thing of beauty inside. She is built to make huge torque.
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