Ipod in the 10 E350 was working fine for the last year until this afternoon, and now a message appears "No Device Connected" and obviously no music.

Ipod works fine when not plugged in the car and is charged.

Command Center is working normally except for this new issue.

The ipod turns on when the car is started and shuts off when the car is turned off.

I have unplugged and plugged back in several times.

Anyone run into this or have suggestions?

try in another vehicle, at the dealership... if it does the same then it is your ipod, if it doesn't then have service, service the cable.

I would make sure your ipod is up to date

It seems to me that the iPod is not paired to the car. My iPhone does this sometimes when using the bluetooth.

I am curious about your comment of "pairing the IPOD" can you explain?