IBY

Hi guys i really need your help in figuring out if it will be safe to fit 16x7.5 ET45 wheels on my w210 e320 4matic. The stock wheels are the same size as the new ones i am looking at, but have an offset of 41, while the new ones im looking at have an offset of 45, this is pretty much what im worried about, will i need spacers? will the wheel rub something important in the fender like the suspension? will 45 offset be bad for the 4matic system somehow compared to 41 offset? Your thoughts would greatly be appreciated, also would anything under 41 ossfet be ok, lets say 35 all the way up to 41, thanks.