Staggered Spacers on W211 4matic Sport with stock wheels

I would like to put H&R 15mm rear and 10mm front spacers on my 09 E350 Sport 4matic (cubanite silver). Since overall tire/wheel diameters (245/40/18) are the same on all corners, should I be concerned about damage to the differential, transmission, etc.? Any thoughts?
FYI: Only looking for cosmetic improvements with this approach...any handling improvement would be a bonus.
Thanks


