Ok so then going with E63 19" wheel and tire set up is safe for the E550, correct?

Yes. However, the E63 uses 285 in the rear which gives you a .2 difference. If you use 295 there will not be any difference between the front and the rear. I have 295 on 20's on mine slammed with no rubbing. The offset of the wheel that you intend to put on may be a factor on whether you can put 295's on without rubbing.

Them I am going with 245/35/19 & 285/30/19 set up. It gives identical overall diameter and enough room to fit the tires with proper E63 wheel offset.

19 e63 Amg wheels on my 2012 e550 4matic
 

Will these wheels cause me any problems with ride quality or fitment?? I want to replace my 18in Amg wheels for a set of factory 19 Amg e63 wheels and I want to make sure I won't have issues can anyone help??