GLS Class (X166) Produced from 2016 to 2019

GLS450 random Cyl3 and Cyl6 Misfire

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Old Jan 5, 2026 | 01:00 PM
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2017 GLS450, 2013 GL450, RIP 2011 GL450 (totalled)
GLS450 random Cyl3 and Cyl6 Misfire

After being out of town for a few days, I moved the car a few feet into the garage. This morning, I cranked her up and could tell immediately something was not right and the car was running rough. Check engine illuminated (but never flashed), and the car ran rough for several miles clearly misfiring and shaking with limited power. My scanner showed random misfire code, and misfires on Cyl3 and Cyl6. I turned the car off and on at a traffic light, and voila, all was gone--including the check engine light. What in the hell could that be?

The cam phaser makes a bit of noise on cold start but is not very noticeable. No other codes on the MBII scanner besides the misfires.

My understanding is 3 and 6 are the rear-most cylinders.
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Old Jan 5, 2026 | 03:18 PM
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John CC's Avatar
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From: New Hampsha
'17 GLS450, '14 GLK250, Grandpa's Roadster
Mine did the same thing a few years back. I don't recall there being a code for a specific cylinder(s), but I probably didn't use an MB specific scanner. Called the dealer and was told "that happens once in a while" or something similar. Hasn't happened since...

In other words, I wouldn't worry unless it happens more often.
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Old Mar 24, 2026 | 10:29 AM
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2017 GLS450, 2013 GL450, RIP 2011 GL450 (totalled)
Yea mine only did it once and has never done it since.
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