Hello All,
Just took ownership of S560 4Matic 2019, RF tires, with 20 inch wheels. Was driven by dealership owner and had 4000 miles when I got it. Highway driving is .... amazing.

HOWEVER - I notice that when vehicle comes to a full stop (no matter how gentle I am with brake pedal) the last second it jerks as if the wheels are locking.

After stopping at light, and the engine shuts off, .... there is also a jerk or double jerk accelerating to begin to drive. Even if the gas pedal is touched gently, I feel the jerk/s.

Driving in the city streets, the ride IS NOT as smooth as my old S550 with 19 inch wheels. Feel thrown around inside the vehicle when roads are not 100% smooth. This may be the RF tires I read about OR is the air suspension not as protective as it was on the S550?

Love to Hear from your experiences about the above.

Sounds normal. Brakes grab as the rotor approaches zero speed. If your vehicle has ECO start/stop it’s not unusual to feel a jerk of some kind. Run flat tires are terrible for ride quality, this is almost 100% unanimous across all vehicle brands. Did you have run flats on your S550?

I think it's normal as long as it's similar to your old S550. If the jerk is more aggressive than your previous S550, than you might have an issue and need MB to look at it.
As far as driving comfort, RF tires can't be compared to standard tires. I decided to use normal/standard tires instead of RF!. For long trips, use road assistance (depending on your route, or keep a small spare tire with u, there is a thread about this) to enjoy comfort ride all the time, that's the only way.

My S550 had 19inch NON RF
And yes - what a smooth ride.
Have to decide....
Replace 20inch RF tires to NON RF - hoping it will be good enough, OR replace to 19 inch wheels with NON RF
decisions decisions

press the ECO (A) button to off every time you drive the car. jerking problem solved. hope this helps. enjoy the car