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I picked up my S580 AMG Line two months ago with the great looking AMG 21" wheels. Two of the tires had small bubbles on the sidewalks from crashing through potholes and the dealer installed new Pirellis on both before I took delivery. I made a mental note to go to a smaller rim given the abundant potholes where I live and positive reports from other forum posts. The manager at the tire shop (Pirelli distributor) I frequent mentioned he had a repeat customer he'd been recommending to make the switch but kept coming back for new tires, another good reference point for the switch.
Initial impressions since yesterday: more compliant ride, slightly quieter too. I still need to see how they do at higher speeds. Visually I liked the AMG wheels but these look pretty good too. Before and after are below; OEM AMG Asanti Black Label