Looking at a 10 E63, what are the problem areas to look for?
It is blk on blk and interior is in great shape. Does have 122k miles but car looks great. Besides changing all the fluids when I get it, anything else to do?
TIA

Well look into the head bolts. Lots of threads on that. I think it was fixed til sometime in 2011. Then there's airmatic and I think there's also a bunch of other engine issues but the major one would be the head bolts. May already have been replaced though. Then there's airmatic and a bunch of other things. Brakes are also way more expensive than E350 ones. In general an AMG is not a cheap car to own/maintain.

Cheapest front brake rotors are about 400 to 500 each. OEM will be over 700.00 each. Proper brake pads $$$$. Spark plus 10+ dollars each for quality proper spark plus. Cabin air filter, cabin charcoal filter. IMO it is best to go with a 2011 or later unless head bolts have definitely been replaced. If you have a scanner that reads all the details of a Mercedes and you are a DIY type of person then its not to expensive to keep up the E63 but otherwise its an expensive car to maintain and some insurance companies will not insure it. At 122,000 miles it most likely needs a lot of services which could add up to over 5000.00.
Plugs, Fluids, Filters, brake fluid flush, brakes, wheel bearing service, rear diff service, fuel filter, radiator flush, transmission service.

Agree with the point about the DIY advantage. Not counting investment in tools and time, the DIY cost advantage is an order of magnitude better than at the Mercedes dealer. Basically, the cost of typical parts and fluids is not much different than other brands. By that I mean quality OEM and aftermarket parts of comparable size/complexity. If one shops around, good deals are possible to find. For example, I just bought a new set of 8 NGK Laser Iridium spark plugs for $49.59 after tax on eBay (item # 143392948864). This is $6.20/ea, and still available at the time of this writing. Many DIY folks, this author included, enjoy/do not mind the experience.

I'd have to be really comfortable with the service history in order to purchase a 10 year old 122K mile E63,

As soon as you buy the car or if you can before buying the car, have a look under the cylinder head covers for camshaft and lifter wear. Its a common thing for m156 engines to eat camshafts. The consequences are a destroyed engine if you neglect it and your mileage is about where it manifests its self. Ofcourse depending on the previous owners maintenance and driving style. So have a look u der the covers fairly easy. And have a look at “tasos moschatos” on youtube.

Ditto from another hardcore DIY guy. Conversely, I wouldn't recommend anyone buy a used AMG unless they kept back a sizable emergency fund for maintenance and repairs. Paying a shop for care and feeding is expensive.