It does sound like an alternator grounding problem. It would be a good idea to check alternator ground, and also the grounding straps in the engine compartment - they are usually a flat braided wire, and if I recall correctly, there are three in a W220; I don't know about a CLK. Be sure the contacts at each end of the straps are clean. There are spray-on products sold that claim to improve the quality of the contact and prevent corrosion.
A problem with spark plugs or wires would sound like pops and a buzz, not a high-pitched whine.
Aside from that, had you made any electrical or audio system changes just before the problem developed?
Last edited by Skylaw; Oct 6, 2009 at 04:18 PM.