GS350 V E350
I don't have direct comparison experience, but I now drive an E400 and previously drove a 2001 LS430 for almost 15 years.
If you can tell us more about which models/options you are considering, we can offer more specific opinions.
In general, my opinion is that your total cost of ownership will likely be less on the GS, but the E350 will be a more engaging car to drive.








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I used to drive 2000 GS400 then 2007 E550 so I am very familiar with how Lexus and Mecedes differ in many ways.
I believe one of the biggest misconception is that Lexus is cheaper than Mercedes to maintain. That's totally false. I still own Lexus GX470 also. To get services from dealer, they are about the same. Failure rate on various parts are about the same, too, at least for E-class which one of the most reliable model among Mercedes line-up.
For the parts, Lexus tends to be higher than Mercedes for most wear and tear items as well commonly replaced parts on suspension.
On the driving side, GS350 feels somewhat sportier but overly refined compared to E350 which feels more raw and solid. Gear shifting is slower in GS350 as well. GS350 feels more cramped inside for both front and rear seats. However, it's a little quieter in GS350 and build material is a little better also.
Lexus really tried hard to make GS a sport sedan, but they just don't know how to make it right like Germans. They do make good trucks and luxury sedans with comfy suspensions.
Also, if you want to spice things up a bit, go for the E400. It will run circles around the GS, although it is a bit more costly.




My experience has been Japanese build more reliable, less costly to own cars. Maintenance will be cheaper in a Toyota product if you keep the car a long time. MB parts and services for major items are expensive.
Incidentally, you are asking MB E Class people which they recommend. Not a totally unbiased group. Assume you have posted question on similar Lexus site.
Last edited by El Cid; Apr 11, 2016 at 10:05 AM.
I was going to say something like that, but my prior experience with MB was quite a while ago. I had a 1988 190E 2.3 (purchased new) for 8 years, and by the time I sold it, the annual repair and maintenance costs were equal to probably half the cash value of the car annually.
By the time my Lexus LS430 got to that point (annual repair costs equal half the cash value of the car), it was over 14 years old.
The Japanese cars seem to just keep going and going (think "Energizer Bunny") but the driver engagement factor is enough to bring me back to the German autos.
The GS350 is Lexus attempt to build a BMW 535 (Motor Trend said it succeeded), particularly if you get a model with the F sport option. I much prefer the drive train of the Lexus (engine & trans). The Lexus transmission is 8 speed and is much superior to the MBZ. The Lexus always seems to be in the right gear, downshifts without delay, and will hold a gear without upshifting too quickly under aggressive driving. It also has rev matching. Every Mercedes I have driven, my E's and even a brand new C that I recently drove, all up shift too soon under all driving conditions(even in sport mode) in my opinion. When you put the Lexus into sport mode, significant changes happen! The trans will really hold a gear, throttle gets more aggressive, the steering gets more aggressive, and suspension is tightened up.
So contrary to what a previous poster said, I think the Lexus is more of a drivers car. Also, Lexus comes with more options standard. Even standard sound system is far superior to the Mercedes HK premium sound system.
The E350 has a lot going for it too. It has MBZ prestige and style. Lexus is somewhat band and looks like other Toyota/Lexus models. MBZ is quieter inside, and has that stable German feel to the ride. The Lexus feels a little light somehow, and is very "pitchy" and dives forward easily when braking. I prefer a lot of the systems on the MBZ, although the Lexus appears more hi tech, it does not equate to easy or efficient operations. No folding down back seats in Lexus either. MBZ has better blind spot monitor system too.
But as I said you can't go wrong with either car!
My thoughts, exactly!
Also, my comparison may not be an exact one, since I only drove the GS350 as a short-term loaner, and I am comparing it to an E400. I guess the debate could go either way comparing the GS350 to the E350. The E400 is a somewhat different animal.
The new GS350's engine is the same but the transmission is new, its a very nice engine, port and direct injection, but it does not have the low end torque found in the turbocharged E400. The new GS350 F sport is a very nice handling car, too bad the front end is ugly as sin and the profile and rear end is bland. Lexus spend a lot of money on the current GS350 and were hoping they would hit a homerun, sales wise, they barely made it onto first base.
I don't want to see a thread about what's more reliable, but my experience with two Lexus has been outstanding. That said, we know our W212 rates exceedingly well in the various reliability tests so I've got my fingers crossed that it'll translate to a low cost of ownership.
More importantly, I'm disappointed with Lexus' product offering. Sales are up and they're making more money than ever, but they're NOT focused on the niche enthusiast segment anymore. I firmly believe they're catering to sheeple that want a lux badge and don't care about performance. It's admittedly working for Lexus, but enthusiasts are left out in the cold which drive me to leave the brand.
* They're STILL using essentially the same 3.5L V6 and 6spd tranny from the '07 GS350 AWD. Just over 300hp, big boring woop. The RWD uses the 8spd tranny, but the AWD still uses the old 6spd.
* They're STILL using the 4.6L V8 in their LS from '09 that is likely a derivative of their older still 4.3L V8 from '02 and maybe their origial 4L V8 from 1990... regardless, it guzzles gas with class-trailing performance.
* Their F-Sport pkgs are lipstick. They're just aesthetic pkgs. Aside from the overweight RC-F (new last year, not awd) and spendy GS-F (new this year, not awd), they use the same powerplants as the standard non-F variants.
All this said, I won't go so far as to say that my old GS was uninspiring or inspiring to drive. It's about as engaging as my E, but it's not like my E requires any special skills to drive or magically tells me what's going on down at the tire contact patches. It just goes down the road where I point it. The Lexus Camry err ES might be a modern day Buick (or LS for that matter), but my old GS and current E aren't much different. I don't get the "appliance" argument.





