There is a condition where if the refrigerant pressure drops too low the compressor will need to be reactivated via the SDS, this to protect the compressor and system components. I replaced my compressor last year, fully recovered the refrigerant and recharged the system and did not have to reset it via SDS. However I did not operate the A/C with the refrigerant low, I was replacing the compressor due to it making the 'I'll die soon, just you watch' noise.
Just re-read your OP, I wonder why replacing the radiator would cause the HVAC system to depressurize?! I replaced mine and did not need to do so.