Need Help diagnosing 2010 S65
The battery is less than 2 weeks old and I charged it overnight and today it still won't start with same results. It is cold today (15F/-10C). I hooked up Autoenginuity and there are a large number of communications related codes.
Here is a list, any help diagnosing would be appreciated:
Timestamp: 1/22/2025 05:29:04 Make: Mercedes Benz Model: S Class Year: 2010 VIN: MIL: Off
Diagnostic Trouble Codes
Generic Powertrain U0121 Lost Communication With Anti-Lock Brake System (ABS) Control Module
Freeze Frame for DTC U0121 Calculated Load 32 % Coolant Temperature 28 F Engine RPM 1467 r/min Vehicle Speed 0 MPH
Enhanced Powertrain CAN ME97 P202a (202A) Unknown Trouble Code Description. Please see your factory service guides for more any information. P20a8 (20A8) Unknown Trouble Code Description. Please see your factory service guides for more any information. P209a (209A) Unknown Trouble Code Description. Please see your factory service guides for more any information. P2080 (2080) Exhaust Gas Temperature Sensor Circuit Range/Performance (Bank 1 Sensor 1)
Fuel Pump Control (FSCU164) U0168:87 (C168) Communication With The Electronic Ignition Lock Has A Malfunction
Transmission (EGS53) U0164 (C164) Communication Disturbance With Control Module N19 (Air Conditioning Control Module).(CAN Timeout Fault) U2318 (E318) Fault In CAN Communication With Component N15/5 (Electronic Selector Lever Module Control Unit) Or A80 (Intelligent Servo Module For DIRECT SELECT). (CAN Timeout Fault) U0121 (C121) CAN Communication With The Traction System Is Faulty.(CAN Timeout Fault) U0141 (C141) Communication Disturbance With Control Module N73 (EIS [EZS] Control Unit).(CAN Timeout Fault) U0155 (C155) Communication Disturbance With Control Module A1 (Instrument Cluster).(CAN Timeout Fault)
Shift Module A80 (DSM) U0121:87 (C121) Lost Communication With Anti-Lock Brake System (ABS) Control Module U0168:87 (C168) Lost Communication With Vehicle Security Control Module U113b:87 (D13B) Unknown Trouble Code Description. Please see your factory service guides for more any information. U0155:87 (C155) Lost Communication With Instrument Panel Cluster (IPC) Control Module U0111:87 (C111) Lost Communication With Battery Energy Control Module A U0128:87 (C128) Lost Communication With Park Brake Control Module U0146:87 (C146) Lost Communication With Gateway 'A'
Electronic Parking Brake (EFB221) C1823 (5823) No CAN Message Was Received From Control Unit N47-5 (ESP Control Unit) C1822 (5822) No CAN Message Was Received From Control Unit N15/3 (ETC [EGS] Control Unit) C1842 (5842) No CAN Message Was Received From Control Unit N80 (Steering Column Module) C1826 (5826) No CAN Message Was Received From Control Unit N47-5 (ESP Control Unit) C1841 (5841) No CAN Message Was Received From Control Unit A80 (Intelligent Servo Module For DIRECT SELECT) C1821 (5821) No CAN Message Was Received From Control Unit Engine Control Module C1825 (5825) No CAN Message Was Received From Control Unit N73 (EIS [EZS] Control Unit)
Airbag (AB221) B1006 (9006) Undervoltage at Tterminal 30 B1007 (9007) Undervoltage at Terminal 15R B119c (919C) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B1181 (9181) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B1182 (9182) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B1187 (9187) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B1188 (9188) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B1189 (9189) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B118a (918A) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B118b (918B) No CAN Message Was Received From Control Unit N73 (EIS Control Module) B11b6 (91B6) CAN Controller: CAN Bus Offin The Case Of The Fault 'Bus OFF' The Control Module Is Isolated From The CAN Bus Because Of A Major Communication Fault
Air Conditioning (KLA221) B100b (900B) Terminal 30 Has Undervoltage Or Overvoltage B120a (920A) A31/1m1 (Circulation Pump): Overload(Overload Is Detected At A Current greater than 2 A.) B1395 (9395) A31/1m1 (Circulation Pump): Short Circuit To Positive Or Open Circuit
Central Controls (CTC) U1000 (D000) Control Unit Central Display is Defective U1909 (D909) Unknown Trouble Code Description. Please see your factory service guides for more any information.
Central Controls Rear (CTCR) U1954 (D954) Fault In CAN Communication With Control Unit N73 (Electronic Ignition Lock Control Unit)
Instrument Cluster (KI221) U001e (C01E) No CAN Message Was Received From Control Unit Adaptive Brake U0026 (C026) Time Out Backbone BSD_LT_STAT U0010 (C010) No CAN Message Was Received From Control Unit Adaptive Brake U0018 (C018) No CAN Message Was Received From Control Unit Adaptive Brake U001d (C01D) No CAN Message Was Received From Control Unit Adaptive Brake U0011 (C011) No CAN Message Was Received From Control Unit Steering Column Module U0012 (C012) No CAN Message Was Received From Control Unit Engine Control Module U0025 (C025) No CAN Message Was Received From Control Unit Engine Control Module U0038 (C038) Vehicle Communication Bus B Performance U0003 (C003) No CAN Message Was Received From Control Unit EZS
ASSYST (WIA) B0704 (8704) Control Unit ASSYST Is Not Receiving Any Messages From The Engine Compartment CAN Bus
ASSYST Plus (WR) B0506 (8506) Communication Error With Instrument Cluster
Overhead Control Panel (OCP221) B1001 (9001) The Voltage Was Less Than 9 V During 5 S
Upper Control Panel (UCP221) B1030 (9030) No CAN Message Was Received From Control Unit N93 (Central Gateway Control Unit).Failure Of CAN Message 'Status 'SRS Indicator Lamp B1043 (9043) Button 'Right Front Reading Lamp' Remains In The Switched State (Contact Sticks)
Signal Acquisition - Driver (SAMF221) B1041 (9041) Component M13 (Heating Water Circulation Pump) Has An Overload Or Short Circuit Or The Line To The Component Has A Short Circuit Or Open Circuit B1090 (9090) Component E6/1 (Left Front Side Marker Lamp USA) Is Faulty Or The Line To The Component Has A Short Circuit Or Open Circuit B10d0 (90D0) Component Switch Illumination Or Line To Component Has Short Circuit Or Open Circuit B1101 (9101) The Coolant Level Is Too Low Or The Line To Component S41 (Coolant Level Indicator Switch) Has An Open Circuit B1102 (9102) The Washer Fluid Level Is Too Low Or The Line To Component S42 (Windshield Washer Fluid Level Indicator Switch) Has An Open Circuit B1121 (9121) Local Undervoltage Of Component M6/6 (Master Wiper Motor) B1200 (9200) Circuit 30 Has An Undervoltage Of less than 10.5 V B1202 (9202) Circuit 30 Has An Undervoltage Of less than 7 V
Steering Column Module (MRM221) U11a3 (D1A3) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1198 (D198) Unknown Trouble Code Description. Please see your factory service guides for more any information. U0146 (C146) Lost Communication With Gateway 'A' U0168 (C168) Lost Communication With Vehicle Security Control Module U1027 (D027) Unknown Trouble Code Description. Please see your factory service guides for more any information. U0142 (C142) Lost Communication With Body Control Module 'B'
Gateway (CGW221) B1010 (9010) Low Supply Voltage, Less Than 9-10 Volts
Audio Command Display ZAN (DISPC211) U1010 (D010) The Supply Voltage of the Control Unit is Too Low
Head Unit (HU204) U1219 (D219) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1155 (D155) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1152 (D152) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1022 (D022) MOST Communication Has A Malfunction (Ring Break At Position 5)
Last edited by auburn2; Jan 22, 2025 at 09:06 AM.




I can tell you my W221 does not like the cold weather at all.
fit two new batteries (normal maint - big one at the front, another small one under the dash)
clear the gunk (they collect so much detritus when having a temper tantrum you can't get anywhere for the noise - most of which are lies when the batteries go flat and water gets at canbus junctions under the carpets)
go for a drive come back with latest batch of diagnostic lies
ISMs - die
electroplate speed sensors in the gearbox - die
ABS sensors - die
but nearly all those can be linked to low volt temper tantrums... Never bother with diagnostic checks on these models unless you add a big battery charger in to the mix with known to be perfect fully charged batteries
I can tell you my W221 does not like the cold weather at all.
fit two new batteries (normal maint - big one at the front, another small one under the dash)
clear the gunk (they collect so much detritus when having a temper tantrum you can't get anywhere for the noise - most of which are lies when the batteries go flat and water gets at canbus junctions under the carpets)
go for a drive come back with latest batch of diagnostic lies
ISMs - die
electroplate speed sensors in the gearbox - die
ABS sensors - die
but nearly all those can be linked to low volt temper tantrums... Never bother with diagnostic checks on these models unless you add a big battery charger in to the mix with known to be perfect fully charged batteries
The battery in the engine compartment is 2 weeks old.
I did not know there was a battery under the dash, do I need to pull the dashboard to get to it? I will try to replace it, but it will probably have to wait until this weekend because it is outside and too cold to work on right now.
I don't think there is any water in the floorboards ... and it would be ice right now.
connect up and charge the car using this connection set up (and leave on when doing diagnostics - not meant to connect anything any other way) if yours looks nothing like this and the battery is only a 35 amp one then its the old set up and there's a huge battery in the boot.... but a 2010 should be the set up in the picture and video....
FYI - the older twin battery cars you ONLY connect like this picture
Last edited by BOTUS; Jan 22, 2025 at 10:10 AM.
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I don't think you have a trunk battery. I do think you have an under dash small motorcycle sized battery for your transmission shifter. You can access it from the side of the dash with the door open. There are posts to describe the access. Not hard. But a hassle in the cold.
I would recharge it, erase codes, and try to start it. If it starts, I would re-check codes. Keep us posted.
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I don't think you have a trunk battery. I do think you have an under dash small motorcycle sized battery for your transmission shifter. You can access it from the side of the dash with the door open. There are posts to describe the access. Not hard. But a hassle in the cold.
I would recharge it, erase codes, and try to start it. If it starts, I would re-check codes. Keep us posted.




My W221 hates this cold weather also. I went to cold start it in 15 degree weather, and she complained but started but showed a red trunk light image on the dash. I am guessing a buildup of ice but who knows. The message went away after the car warmed up. As I get older, I don't like cold weather either......
I pulled the battery and I am going to take it into AA to get tested tomorrow.
I put the battery back in the car today. The dash warnings went away and the car started, the presafe brake and other related features are online. It idles fine but there is no response to throttle input. The car shifts fine through P-R-N-D. Most of the trouble codes went away.
I am using an autoenginuity scanner with the enhanced Mercedes package. It is not showing anything for the throttle pedal position sensor. A lot of the other powertrain sensors are not showing up on the scanner either. The OBD-II sensors are showing up though. Alternator putting out 14.5 Volts and shown both on the dash and in the OBD-2 scanner readout.
I am going to try to replace the little battery in the instrument panel today. I have not messed with any wiring recently except around the battery and that looks ok. If the new little battery doesn't fix it I think it is probably a problem with the communication system or a module (SAM maybe?)
Most of the codes went away following are the only ones remaining:
Electronic Parking Brake (EFB221) C1821 (5821) No CAN Message Was Received From Control Unit Engine Control Module
Air Conditioning (KLA221) B1395 (9395) A31/1m1 (Circulation Pump): Short Circuit To Positive Or Open Circuit
Signal Acquisition - Driver (SAMF221) B1041 (9041) Component M13 (Heating Water Circulation Pump) Has An Overload Or Short Circuit Or The Line To The Component Has A Short Circuit Or Open Circuit B1090 (9090) Component E6/1 (Left Front Side Marker Lamp USA) Is Faulty Or The Line To The Component Has A Short Circuit Or Open Circuit B10d0 (90D0) Component Switch Illumination Or Line To Component Has Short Circuit Or Open Circuit B1101 (9101) The Coolant Level Is Too Low Or The Line To Component S41 (Coolant Level Indicator Switch) Has An Open Circuit B1102 (9102) The Washer Fluid Level Is Too Low Or The Line To Component S42 (Windshield Washer Fluid Level Indicator Switch) Has An Open Circuit B1121 (9121) Local Undervoltage Of Component M6/6 (Master Wiper Motor) B1200 (9200) Circuit 30 Has An Undervoltage Of less than 10.5 V B1202 (9202) Circuit 30 Has An Undervoltage Of less than 7 V
Steering Column Module (MRM221) U11a3 (D1A3) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1198 (D198) Unknown Trouble Code Description. Please see your factory service guides for more any information. U0146 (C146) Lost Communication With Gateway 'A' U0168 (C168) Lost Communication With Vehicle Security Control Module U1027 (D027) Unknown Trouble Code Description. Please see your factory service guides for more any information. U0142 (C142) Lost Communication With Body Control Module 'B'
Gateway (CGW221) B1010 (9010) Low Supply Voltage, Less Than 9-10 Volts
Audio Command Display ZAN (DISPC211) U1010 (D010) The Supply Voltage of the Control Unit is Too Low
Head Unit (HU204) U1219 (D219) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1155 (D155) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1152 (D152) Unknown Trouble Code Description. Please see your factory service guides for more any information. U1022 (D022) MOST Communication Has A Malfunction (Ring Break At Position 5)
Satellite Digital Audio Radio N87/5 (SDAR221) U1010 (D010) The Power Supply is too low U1250 (D250) This Control Module Does Not Match To The Coded Model Designation
Last edited by auburn2; Jan 25, 2025 at 12:38 PM.




I pulled out the dash battery and put in a replacement from batteries plus. After I put that in it initially started up and drove normally with no problems, after a few minutes of driving I lost pre safe braking, adaptive cruise and had a right SRS malfunction, it still drove fine though, and restarted again after I shut it off (continued to get the SRS and presafe warnings). I have no CEL and have not had one the entire time.
The Presafe braking and cruise has been flaky for years, and turns itself off occasionally (not often, like once a month maybe). It usually comes back on after a few minutes driving or when I turn the car off and turn it back on. The SRS has never had a problem before.
I have not pulled the codes since the last time I drove it. Assuming it keeps driving I am going to drive it this week and see if it clears itself after a few starts. I am also going to look at some of the wiring diagrams in WIS and look at the SRS system and presafe brake and see if there are anything common that could cause a failure in both.
Last edited by auburn2; Jan 25, 2025 at 04:21 PM.




and the pre-safe issue is also a bit weird.... its part of the radar set up of distronic plus, tries to work out if you're crashing and sets the car up for a more comfy smash - I'm guessing ABS sensor or crash sensor throwing ESP a curve ball - ever had a tiny prang ? its enough to make the chassis leg sensors throw teddies easy and cheap to replace but it will have a code for them
Last edited by BOTUS; Jan 25, 2025 at 05:05 PM.
and the pre-safe issue is also a bit weird.... its part of the radar set up of distronic plus, tries to work out if you're crashing and sets the car up for a more comfy smash - I'm guessing ABS sensor or crash sensor throwing ESP a curve ball - ever had a tiny prang ? its enough to make the chassis leg sensors throw teddies easy and cheap to replace but it will have a code for them
Pre-Safe is what the warning on the dash is saying is inop, but Distronic is also not working and I don't think the blind spot monitors are working either.
According to WIS the DTR (distronic) control unit is powered by fuse F66 in the engine fuse compartment and either relay D or E. These are in the same location as the Front SAM where most of the remaining codes are coming from. Conincedence??
I can't find a relation to the SRS (and now the dash is saying specifically front passenger SRS malfunction).
Pre safe involved in most things - its the beep from the overhead control panel - than can be enabled or not, (with cluster logo to help understand why it beeps incessantly). It watches your driving waiting to see if your driving style or other road users get in your way (within it pre build rules), it either beeps (which changes in number and cadence based on the edition of software in the Rear SAM) or when it really believes you are going to crash AND you then bother to start to brake - it smashes the brake pedal to the floor - moves the seats to a better crash position - pumps up the seat cushion bolsters - snatches the seat belts tight - arms air bags for a big reaction - unlocks the doors - and closes the windows . It certainly makes the passengers get a fright even if you can see you'll stop comfortably.
Botus... My 221 S-65 was very good at letting me know when I was being a savage as ‘Pre-Safe’ with all the noise, seats moving ect would do it’s thing with many turns. Until I turned it off.
After being charged the main battery tested good. 1100CCAs (rated for 900), 12.8V, reserve capacity good.
It is a lot warmer today (50F/10C). This might be my car's way of telling me Alabama is too far north and I need to move to Miami .... something my bones and the rest of my body are telling me too.
I am going to cross my fingers and hope for the best. Thanks for the help everyone.
P.S. When I got rearended by a Tahoe on the highway and totaled my 2007 S65 all that stuff you talked about Botus happened even though I was hit from behind. The worst was after it ran my seat back I could not reach the pedals well to brake. It also called the mercedes roadside assistance automatically and before I am even stopped I have someone talking to me. It was thoroughly confusing and frightening: No one was hurt, but I am trying to keep from hitting other cars, get it to the side of the road without being able to reach the brakes and I have some unknown person (maybe God ??) talking and asking me if I am ok.




I think your W221 is telling you it is time to go South.






