S-Class (W221) 2007-2013: S 320 CDI, S 350, S 450, S 500, S 550, S 420 CDI, S 600

W221 Electrical Gremlin. Help!

Thread Tools
 
Search this Thread
 
Rate Thread
 
Old Dec 24, 2025 | 06:12 PM
  #1  
221gremlin's Avatar
Thread Starter
Newbie
 
Joined: Dec 2025
Posts: 7
Likes: 2
From: Texas
2010 Mercedes S550
W221 Electrical Gremlin. Help!

Hello Everyone!

I’m having an interesting electrical issue, my 2010 S550 with only 77k miles has no communication with any module through OBD, no start no crank and flickering screen with errors (see video), I’ve put a brand new battery no luck, I’ve bought another gateway to plug in and still same flickering symptoms.

update: we have established connection after unplugging the headlights and connecting the original gateway, we could go into every module except eis so we sent our eis away to a tech and they found that the chip is shorted inside the eis so they replaced it, we now plugged everything in and got a new problem, when we go to crank both screens flicker like crazy as if there is a short somewhere and obviously again no crank!

what could this be?

YouTube link: https://youtube.com/shorts/oFyDjytk630?si=lwxzRTqpSDT-4B-x

Last edited by 221gremlin; Jan 7, 2026 at 10:58 PM. Reason: Update
Reply
Old Dec 24, 2025 | 06:22 PM
  #2  
smiles201's Avatar
Super Member
10 Year Member
Liked
Loved
 
Joined: Dec 2015
Posts: 609
Likes: 242
From: Suburban Maryland
2023 E 450 Sedan. 2018 GLC 300. 2013 E 350 Coupe (retired)
Bad ground?
Reply
Old Dec 24, 2025 | 07:32 PM
  #3  
221gremlin's Avatar
Thread Starter
Newbie
 
Joined: Dec 2025
Posts: 7
Likes: 2
From: Texas
2010 Mercedes S550
Originally Posted by smiles201
Bad ground?
looks like something with wiring, I will check it all out, it’s never been flooded.
Reply
Old Dec 25, 2025 | 05:32 AM
  #4  
BOTUS's Avatar
MBWorld Fanatic!
10 Year Member
Community Builder
Community Influencer
Liked
 
Joined: Aug 2014
Posts: 5,322
Likes: 1,678
S500
Originally Posted by 221gremlin
Hello Everyone!

I’m having an interesting electrical issue, my 2010 S550 with only 77k miles has no communication with any module through OBD, no start no crank and flickering screen with errors (see video), I’ve put a brand new battery no luck, I’ve bought another gateway to plug in and still same flickering symptoms.

what could this be?

YouTube link: https://youtube.com/shorts/oFyDjytk6...xzRTqpSDT-4B-x
gateways are not plug and play

confused gateways give no comms to the ODB2 socket - and a battery reset (disconnect for 20 min) often sorts it out

however the other fun you are having isn't just a battery reset - replacing the other baby motorcycle battery behind the ignition switch likely not a bad idea

look for blown pre fuses and as other's mention poor earths
Reply
Old Dec 27, 2025 | 12:10 PM
  #5  
Arrie's Avatar
MBWorld Fanatic!
15 Year Member
Photogenic
Photoriffic
Liked
 
Joined: Oct 2010
Posts: 5,142
Likes: 1,293
From: Southern US
2010 E550, 273 Engine: 2012 S550, 278 Engine
Originally Posted by 221gremlin
Hello Everyone!

I’m having an interesting electrical issue, my 2010 S550 with only 77k miles has no communication with any module through OBD, no start no crank and flickering screen with errors (see video), I’ve put a brand new battery no luck, I’ve bought another gateway to plug in and still same flickering symptoms.

what could this be?

YouTube link: https://youtube.com/shorts/oFyDjytk6...xzRTqpSDT-4B-x
Like BOTUS already said the CGW is nt plug-and-play, it needs to be coded.

Put the original CGW back in as it may change things if it is the issue with the bad connections between the harness pins and the board, like I had the issue with. Re-connecting the old CGW may move the pins and allow better connection again.

This may be the cluster issue too.
Reply
Old Jan 7, 2026 | 10:58 PM
  #6  
221gremlin's Avatar
Thread Starter
Newbie
 
Joined: Dec 2025
Posts: 7
Likes: 2
From: Texas
2010 Mercedes S550
Update!

update: we have established connection after unplugging the headlights and connecting the original gateway, we could go into every module except eis so we sent our eis away to a tech and they found that the chip is shorted inside the eis so they replaced it, we now plugged everything in and got a new problem, when we go to crank both screens flicker like crazy as if there is a short somewhere and obviously again no crank!
Reply
Old Jan 7, 2026 | 11:18 PM
  #7  
Arrie's Avatar
MBWorld Fanatic!
15 Year Member
Photogenic
Photoriffic
Liked
 
Joined: Oct 2010
Posts: 5,142
Likes: 1,293
From: Southern US
2010 E550, 273 Engine: 2012 S550, 278 Engine
Originally Posted by 221gremlin
update: we have established connection after unplugging the headlights and connecting the original gateway, we could go into every module except eis so we sent our eis away to a tech and they found that the chip is shorted inside the eis so they replaced it, we now plugged everything in and got a new problem, when we go to crank both screens flicker like crazy as if there is a short somewhere and obviously again no crank!
I would look at the starter. When they go bad they can rob the amps/voltage from other modules, so the car won't start even when it cranks fine. Now you say it does it not even crank so I would really look at the starter.


Reply
Old Jan 8, 2026 | 12:40 AM
  #8  
221gremlin's Avatar
Thread Starter
Newbie
 
Joined: Dec 2025
Posts: 7
Likes: 2
From: Texas
2010 Mercedes S550
Originally Posted by Arrie
I would look at the starter. When they go bad they can rob the amps/voltage from other modules, so the car won't start even when it cranks fine. Now you say it does it not even crank so I would really look at the starter.
that’s what I’m also thinking maybe the old owner drove through a big puddle or large amount of water and maybe it corroded the starter and shorting it, I will investigate tomorrow after work!
Reply
MB World Stories

The Best of Mercedes & AMG

story-0

New Electric Mercedes-AMG GT 4-Door Coupe Unveiled: 10 Things You Need to Know

 Verdad Gallardo
story-1

6 Mercedes Models That Did NOT Age Well (But Are Somehow Still Cool)

 Verdad Gallardo
story-2

Manual Mercedes? 6 Times Sindelfingen Let Drivers Have All The Fun

 Verdad Gallardo
story-3

Mercedes SLR McLaren 722 S Is Extremely Rare Example Modified by McLaren

 Verdad Gallardo
story-4

8 Classic Boxy Mercedes Designs That Have Aged Like Fine Wine

 Verdad Gallardo
story-5

Flawlessly Restored Mercedes 190E Evo II Heads to Auction

 Verdad Gallardo
story-6

Electric Mercedes C-Class Unveiled: 11 Things You Need to Know

 Verdad Gallardo
story-7

Mercedes EQS Gets A Major Update: Everything You Need to Know

 Verdad Gallardo
story-8

5 Underrated Mercedes-Benz Models That Don't Get the Love They Deserve

 Verdad Gallardo
story-9

Mercedes 300D Has Pushed Well Past 1 Million Miles and It Ain't Stopping

 Verdad Gallardo
Old Jan 8, 2026 | 01:09 PM
  #9  
JohnLane's Avatar
MBWorld Fanatic!
10 Year Member
Community Builder
Community Influencer
Loved
 
Joined: Feb 2012
Posts: 2,641
Likes: 1,224
From: Phoenix
222 S-65
Or maybe... Just maybe it; at the tender age of 15 is old enough that a starter, Central Gateway, EIS or any of the other myriad issues that happen that can be a real treat to sort out have failed.

May the Force be with you Friend.
Reply
Old Jan 9, 2026 | 12:39 AM
  #10  
BOTUS's Avatar
MBWorld Fanatic!
10 Year Member
Community Builder
Community Influencer
Liked
 
Joined: Aug 2014
Posts: 5,322
Likes: 1,678
S500
if you are running a late spec CGW that is not programmed with the correct software iteration and coded to suit options on the car - it can not operate correctly - indeed I presume damage could be achieved
Reply
Old Jan 9, 2026 | 09:56 AM
  #11  
AL5461's Avatar
Super Member
Photogenic
Community Builder
Liked
Loved
 
Joined: Oct 2023
Posts: 568
Likes: 197
W221 S500
Never flooded? Are you sure about that? Lift the front carpets and check for ANY signs of moisture in the CANBUS junctions and treat it accordingly.

For testing purposes, the CGW can be swapped for another. True some features may not function, unless it's correctly optioned. From experience this is easily done using Xentry... However, you cannot change Vehicle Vin or Mileage after the initial programming of the CGW and you will get a code for the VIN mismatch.
Reply
Old Jan 9, 2026 | 10:16 PM
  #12  
221gremlin's Avatar
Thread Starter
Newbie
 
Joined: Dec 2025
Posts: 7
Likes: 2
From: Texas
2010 Mercedes S550
Latest update. Car started

Originally Posted by 221gremlin
Hello Everyone!

I’m having an interesting electrical issue, my 2010 S550 with only 77k miles has no communication with any module through OBD, no start no crank and flickering screen with errors (see video), I’ve put a brand new battery no luck, I’ve bought another gateway to plug in and still same flickering symptoms.

update: we have established connection after unplugging the headlights and connecting the original gateway, we could go into every module except eis so we sent our eis away to a tech and they found that the chip is shorted inside the eis so they replaced it, we now plugged everything in and got a new problem, when we go to crank both screens flicker like crazy as if there is a short somewhere and obviously again no crank!

what could this be?

YouTube link: https://youtube.com/shorts/oFyDjytk6...xzRTqpSDT-4B-x
ok guys the car has finally started, i got back the eis from the tech and he found a bad chip that overheats and shuts down the eis. Now the car sometimes starts but it also starts glitching when it wants to and loses connection with all modules and sometimes again can’t be started. New video link attached.

Reply
Old May 20, 2026 | 04:31 PM
  #13  
221gremlin's Avatar
Thread Starter
Newbie
 
Joined: Dec 2025
Posts: 7
Likes: 2
From: Texas
2010 Mercedes S550
Smile SOLVED!

The problem with 2010 S550 is finally solved.

Issue was in the EIS shorting inside and causing electrical problems, replaced it and coded now its all working again
Reply

Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 


You have already rated this thread Rating: Thread Rating: 0 votes,  average.


All times are GMT -4. The time now is 07:30 AM.

story-0
New Electric Mercedes-AMG GT 4-Door Coupe Unveiled: 10 Things You Need to Know

Slideshow: Mercedes-AMG's new electric GT 4-Door Coupe trades combustion for software, synthetic noise, and more than 1,100 horsepower.

By Verdad Gallardo | 2026-05-20 20:08:15


VIEW MORE
story-1
6 Mercedes Models That Did NOT Age Well (But Are Somehow Still Cool)

Slideshow: Not every Mercedes design becomes timeless, some feel stuck in the era they came from.

By Verdad Gallardo | 2026-05-12 18:09:07


VIEW MORE
story-2
Manual Mercedes? 6 Times Sindelfingen Let Drivers Have All The Fun

Slideshow: Yes, Mercedes built manual cars, and some of them are far more interesting than you'd expect.

By Verdad Gallardo | 2026-05-02 12:36:58


VIEW MORE
story-3
Mercedes SLR McLaren 722 S Is Extremely Rare Example Modified by McLaren

Slideshow: A one-of-one U.S.-spec Mercedes-Benz SLR McLaren Roadster became even rarer after a factory-backed transformation at McLaren's headquarters.

By Verdad Gallardo | 2026-04-29 11:19:28


VIEW MORE
story-4
8 Classic Boxy Mercedes Designs That Have Aged Like Fine Wine

Slideshow: Before curves took over, Mercedes mastered the art of the straight line, and some of those shapes still look right today.

By Verdad Gallardo | 2026-04-25 12:05:49


VIEW MORE
story-5
Flawlessly Restored Mercedes 190E Evo II Heads to Auction

Slideshow: The 190E Evolution II shows how a homologation necessity became a six-figure collector icon.

By Verdad Gallardo | 2026-04-22 17:53:47


VIEW MORE
story-6
Electric Mercedes C-Class Unveiled: 11 Things You Need to Know

Slideshow: Mercedes is turning one of its core nameplates electric, and the details show just how serious this shift is.

By Verdad Gallardo | 2026-04-21 13:58:06


VIEW MORE
story-7
Mercedes EQS Gets A Major Update: Everything You Need to Know

Slideshow: Faster charging, longer range, and a controversial steer-by-wire system define the latest evolution of Mercedes-Benz EQS.

By Verdad Gallardo | 2026-04-15 10:35:34


VIEW MORE
story-8
5 Underrated Mercedes-Benz Models That Don't Get the Love They Deserve

Slideshow: These overlooked Mercedes-Benz models never got the spotlight, but they quietly delivered more than most remember.

By Verdad Gallardo | 2026-04-13 19:35:45


VIEW MORE
story-9
Mercedes 300D Has Pushed Well Past 1 Million Miles and It Ain't Stopping

Slideshow: A well-used 1991 Mercedes-Benz 300D with more than one million miles is now looking for a new owner, and it still appears ready for more.

By Verdad Gallardo | 2026-04-10 10:05:15


VIEW MORE