For my 4Matic's 255-45 R18 tires, I've had Conti ProContacts for about 70,000 miles now, and I thought to try something new. I'm looking for the quietest, best ride all-seasons and not huge performance.

Michelin Primacy tires seem to get good reviews, but the only GT tires available for our cars are the other OE option, Pilot MXM4, which are dinged pretty good on tirerack reviews. They also don't seem to have low rolling resistance.

Then I keep hearing hardly anything but good things about the Bridgestone Turanza Serenity Plus tires, and that they're the best overall for grand touring tires....However, I noticed that in this size, the only options are 103W rated vs. the Conti's 99H....Typical sizes for the Bridgestones seem to be H rated where a lot of the praises for low noise and comfort probably come from, but I wonder if the higher load and speed rating negates those benefits compared to the more common sizes? Has anyone tried them on W221? Any better riding option than the ProContacts?

If you can't get the Michelin Primacy MXV4, then get the serenitys.

Another slightly sportier option is the Conti DWS

70000 miles for the Contiprocontact is great. My right rear was the first to go, and apparently it is the main drive wheel, so I replaced the back two and stuck with the pro contact. Eventually I hit a curb and blew the front right tire so replaced the front two shortly therafter. I have to say, the price is right($130), the grip is great and ride is soft and quiet. My 2007 S550 has the same great ride and performance. I could've got the Conti DWS series for less, but it doesn't snow here and I did not want to screw with perfection. Though the new procontact tires are not manufactured in germany, they are great (I've got about 10K on it now)

FWIW, I had a bad experience with the bridgestone turanza on my e-class. After about 10K, the tires got really noisy, though they grip was good especially in bad weather. But the noise was the deal breaker.

Hope this is helpful.
V

I just changed from Conti extreme contact dws to the turanza serenity plus on my 07 4matic...I liked the Dws, but the ride on the Turanzas is absolutely incredible...no hesitation..go with Turanza Serenity Plus (make sure "plus" as it is new design)

I LOVE MY DWS CONTI'S

Trust me, these tires' time in the sun has come and gone! Same here, right rear wheel has been rumbling like a thunderstorm for a while now, front left wheel has recently started also, and they've all been quite noisy on the road in their old age.

Yes, I've seen a few reviews about the Serenitys (unsure if Plus) getting noisier as they age, not sure if common or related to load and speed rating.

Many recommendations have come for the DWS as well, more grip less comfort though? The car is riding like it's on square wheels right now so anything will be an improvement!

70,000 miles is extremely good. I doubt any other tires will last even half of that. I would replace with the same tires. I have staggered wheels and get only about 15,000 miles for the rear and 30,000 miles for the front tires,

+ 1 for the Conti Contact Extreme DWS. I live in strong four season Wisconsin.