W222 does seem to have a wheel well for a spare tire
I just got a W222 S550 (this replaced a 2012 W221 S550). I noticed that when the trunk floor liners (2 separate layers) are lifted up, there appears to be a regular wheel well for a spare tire (may even hold a full sized spare, not just a donut). The problem is that the battery is mounted in the middle of this well. I am going to look into relocating the battery in the back of the trunk so that this precious wheel well is not wasted and can hold a full-sized spare (rescued from the old 2012 S550). Will update when I get going on this project. Unless it is easier to just carry the spare in the trunk (local driving) or back seat (long-distance trips when trunk space is needed for luggage). From my numerous experiences with many different cars (3 S-class sedans, Porsches, BMWs), it is unthinkable to drive out of town without a spare. In fact all my cars (except for an electric Porsche driven only locally) carry full-sized spares. For our previous 2012 S550, I removed the staggered AMG 20" wheels (after 2 blowouts, one of which could have led to many deaths) and bought 5 identical 19" wheels and Pilot-sport tires; the 5th one sat perfectly in the trunk's well after removing the 2nd partitioning layer. I rescued it and now hope to fit it into the trunk well of the W222. We will see how it goes!