M278 Cylinder 4 misfire
When I got the car, replaced camshaft on passenger side, all the cam gear adjusters, timing chain, coolant lines for the turbos, spark plugs, coil wires, and all 4 O2 sensors. Also replaced all brake pads and rotors. Aux battery replaced just before 100k miles and transmission service completed at 100k.
Modifications: Pressertech Stage 2 tune, intake spacers, BMC air filters, exhaust resonators deleted and an X-pipe put in, aluminum intake pipes, and Creative Steel motor mounts to handle the increased power.
As some preventive measures I installed cam sensor harness extenders, and the oil pump solenoid mod.
The rear subframe was replaced under a factory recall and the springs were as well because they rusted out. Also, the coolant inlet pipe in the back of driver side head was replaced with the updated version. New blower motor and resistor for the HVAC.




When I got the car, replaced camshaft on passenger side, all the cam gear adjusters, timing chain, coolant lines for the turbos, spark plugs, coil wires, and all 4 O2 sensors. Also replaced all brake pads and rotors. Aux battery replaced just before 100k miles and transmission service completed at 100k.
Modifications: Pressertech Stage 2 tune, intake spacers, BMC air filters, exhaust resonators deleted and an X-pipe put in, aluminum intake pipes, and Creative Steel motor mounts to handle the increased power.
As some preventive measures I installed cam sensor harness extenders, and the oil pump solenoid mod.
The rear subframe was replaced under a factory recall and the springs were as well because they rusted out. Also, the coolant inlet pipe in the back of driver side head was replaced with the updated version. New blower motor and resistor for the HVAC.
You said nothing about your 3x fuel pumps... what are your fuel tank & rail pressures and cyl. compressions?
Last edited by CaliBenzDriver; Mar 5, 2026 at 06:27 PM.
When I got the car, replaced camshaft on passenger side, all the cam gear adjusters, timing chain, coolant lines for the turbos, spark plugs, coil wires, and all 4 O2 sensors. Also replaced all brake pads and rotors. Aux battery replaced just before 100k miles and transmission service completed at 100k.
Modifications: Pressertech Stage 2 tune, intake spacers, BMC air filters, exhaust resonators deleted and an X-pipe put in, aluminum intake pipes, and Creative Steel motor mounts to handle the increased power.
As some preventive measures I installed cam sensor harness extenders, and the oil pump solenoid mod.
The rear subframe was replaced under a factory recall and the springs were as well because they rusted out. Also, the coolant inlet pipe in the back of driver side head was replaced with the updated version. New blower motor and resistor for the HVAC.
a leak down/compression test will be great as well, but start with checking the plugs.




MB misfires have many sources: lean trims require scanner to read LTFT.
Not swapping good parts blindly saves ressources: time & money.

So OP def should look at his spark plugs. He should also buy an Autel or something that can give him fault code readings and live data. But to say not to troubleshoot by swapping parts should be your opinion, and should be a valid TS step.
Last edited by Billyismyname; Mar 6, 2026 at 10:17 PM.




GL and please keep us posted.
Cheers,
maw
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So OP def should look at his spark plugs. He should also buy an Autel or something that can give him fault code readings and live data. But to say not to troubleshoot by swapping parts should be your opinion, and should be a valid TS step.
I was referring to ppl who replace all their genuine ignition parts blindly with aftermarket to only get no improvement.
OBDII Scanner can save a great deal of time up front.

Last edited by CaliBenzDriver; Mar 6, 2026 at 11:28 PM.
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A compression test showed over 150 in that cylinder, so I don't think that's the issue. I reinstalled all the plugs and coils in reverse order to see if the misfire moved at all, and still got it at #4, so I'm leaning heavily towards bad injector.
Life stuff happened, and I didn't get around to testing the fuel pressure, but I would think the whole bank would have a misfire or there would have been a code if one of the pumps was bad.
When I get the chance, I am going to move the injector to another cylinder and see what happens.
A compression test showed over 150 in that cylinder, so I don't think that's the issue. I reinstalled all the plugs and coils in reverse order to see if the misfire moved at all, and still got it at #4, so I'm leaning heavily towards bad injector.
Life stuff happened, and I didn't get around to testing the fuel pressure, but I would think the whole bank would have a misfire or there would have been a code if one of the pumps was bad.
When I get the chance, I am going to move the injector to another cylinder and see what happens.
Do your self a favor and buy an Autel 808S (you do not need anything fancier, and I'd steer away from those Mercedes specific diags as they're a waste of money. These Autels work for every vehicle and they do the same exact thing the MB specific 3rd party diags do) You can buy the Autel that I have for $380 off of ebay directly from Autel https://tinyurl.com/AutelEbay or buy it off of amazon for $100 more than eBay. This diag is amazing. I actually use it for everything (including doing a valve flush transmission service on my W213 that not a lot of scan tools can do). I've also programmed my Bosch injectors with this Autel.
You just need to take a picture of the serial number on the injector and put in the new number in the autel tool to let the ECU know which injector is in which cylinder so you don't have any issues with spray patterns and such.
not sure what year and model your e class is, but i assume it's either an E500 or E550 since you said it's an M278 engine? If so, don't buy a Mercedes OEM injector. buy a bosch one instead. You'll save $300-$500 per injector. I replaced all of my injector with Bosch OE units and they've been working like a charm ever since. Bosch is who makes the injectors anyways for MB so there is no difference in quality other than the price.
Last edited by Billyismyname; Mar 7, 2026 at 11:26 PM.
Do your self a favor and buy an Autel 808S (you do not need anything fancier, and I'd steer away from those Mercedes specific diags as they're a waste of money. These Autels work for every vehicle and they do the same exact thing the MB specific 3rd party diags do) You can buy the Autel that I have for $380 off of ebay directly from Autel https://tinyurl.com/AutelEbay or buy it off of amazon for $100 more than eBay. This diag is amazing. I actually use it for everything (including doing a valve flush transmission service on my W213 that not a lot of scan tools can do). I've also programmed my Bosch injectors with this Autel.
You just need to take a picture of the serial number on the injector and put in the new number in the autel tool to let the ECU know which injector is in which cylinder so you don't have any issues with spray patterns and such.
not sure what year and model your e class is, but i assume it's either an E500 or E550 since you said it's an M278 engine? If so, don't buy a Mercedes OEM injector. buy a bosch one instead. You'll save $300-$500 per injector. I replaced all of my injector with Bosch OE units and they've been working like a charm ever since. Bosch is who makes the injectors anyways for MB so there is no difference in quality other than the price.
Car is a 2012 E550 4-matic, and if you have the right injector, I'll take it for testing. I did find some Bosch injectors on ebay for $80, so i may just go ahead and get it and send it back if its not the issue.
Car is a 2012 E550 4-matic, and if you have the right injector, I'll take it for testing. I did find some Bosch injectors on ebay for $80, so i may just go ahead and get it and send it back if its not the issue.
They are the exact same ones I have in my Mercedes:
I have these four that are in the picture (the OEM ones that came in my E Class). I am really not sure which one of them is faulty. But I can send two to you just in case you do end up installing the one that is leaking if you want to test. They're not hard to replace, but you WILL need to code them in. So I'd suggest buying that Autel. If it ends up fixing your issue, you can keep the injectors I send you. It'll atleast cover half of the cost of the Autel diag tool to save you some money.
Let me know if you want me to send you them.
**Edit - I actually do know which one is faulty. It's the Cyl #4 injector, you can see in the picture it's a lot more corroded than the rest). I just found it and tossed it in the trash so I can send you just the one injector to test**
Last edited by Billyismyname; Mar 8, 2026 at 11:47 PM.
They are the exact same ones I have in my Mercedes:
I have these four that are in the picture (the OEM ones that came in my E Class). I am really not sure which one of them is faulty. But I can send two to you just in case you do end up installing the one that is leaking if you want to test. They're not hard to replace, but you WILL need to code them in. So I'd suggest buying that Autel. If it ends up fixing your issue, you can keep the injectors I send you. It'll atleast cover half of the cost of the Autel diag tool to save you some money.
Let me know if you want me to send you them.
**Edit - I actually do know which one is faulty. It's the Cyl #4 injector, you can see in the picture it's a lot more corroded than the rest). I just found it and tossed it in the trash so I can send you just the one injector to test**



