MY01 W220 S500 mileage - not too bad! :)
Timing isn't vad either
Yes i do see 20+ mpg sometimes when I'm not encountering any traffic.
Actually I noticed (from previous trips) if you keep running at about 70-75 mph then I was able get MUCH better mileage (about 22-23 mpg for 4+ hour trip).
1637 km
125.5 km/h
11 L/100km

The thing about fuel consumption that I noticed (which is different for each car/engine model) is that the best mpg on S500 you can get cruising at 45-70 mph (I usually get around 22.5-22.8 mpg for my NYC-Boston trips), but once you go over 80 mph your fuel consumption increases dramatically...
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